Evidence that pre-existent variability in platelet response to ADP accounts for ‘clopidogrel resistance’
نویسندگان
چکیده
منابع مشابه
Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance': a rebuttal.
BACKGROUND Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y(12) adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel resistance'. OBJECTIVES To determine whether 'clopidogrel resistance' is accounted for by a pre-existent variability in platelet response to ADP. METHODS Platelet response to 20 microm ADP was analyzed by four inde...
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Thromb Haemost 2008; 100: 729–730 Platelet activation plays a central role in haemostasis and thrombosis. Antiplatelet therapy is considered to be the ‘cornerstone’in the prevention and treatment of thrombotic diseases such as coronary artery disease (CAD), stroke and peripheral arterial disease (PAD). While dual antiplatelet therapy with aspirin and clopidogrel is currently the standard therap...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2006
ISSN: 1538-7933
DOI: 10.1111/j.1538-7836.2006.02234.x